Interview with Nobel Laureate Dr. Andrew Fire

by David Lemberg on August 15, 2008

in Genetics and Genomic Medicine

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Dr. Andrew Fire is the co-discoverer of RNA interference. He is the 2006 Nobel Laureate in Physiology or Medicine, and Professor, Departments of Pathology and Genetics, Stanford University School of Medicine.

Dr. Fire’s lab studies the mechanisms by which cells and organisms respond to genetic change.

The genetic landscape faced by a living cell is constantly changing. Developmental transitions, environmental shifts, and pathogenic invasions lend a dynamic character to both the genome and its activity pattern. The Fire Lab studies a variety of natural mechanisms that are utilized by cells adapting to genetic change.

These include mechanisms activated during normal development and systems for detecting and responding to foreign or unwanted genetic activity. At the root of these studies are questions of how a cell can distinguish “self” versus “nonself” and “wanted” versus “unwanted” gene expression.

The Fire Lab primarily makes use of the nematode C. elegans in experimental studies. C. elegans is small, easily cultured, and can readily be made to accept foreign DNA or RNA. The results of such experiments have outlined a number of concerted responses that recognize (and in most cases work to silence) the foreign nucleic acid. One such mechanism (RNAi) responds to double-stranded character in RNA: either as introduced experimentally into the organism or as produced from foreign DNA that has not undergone selection to avoid a dsRNA response.

Much of the current effort in the lab is directed toward a molecular understanding of the RNAi machinery and its roles in the cell. RNAi is not the only cellular defense against unwanted nucleic acid, and substantial current effort in the lab is also directed at identification of other triggers and mechanisms used in recognition and response to foreign information.

In our wide-ranging SCIENCE AND SOCIETY interview, done on 1-10-07, Dr. Fire discusses

  • Process of discovery of RNA interference
  • How can cellular machinery recognize certain informational molecules as ‘unwanted’
  • How can the cell use this recognition to effectively silence malicious genetic activity
  • RNA interference vs. “traditional” immunity
  • Physiological factors modulating RNA interference to allow maximal response to pathogen RNAs
  • Mechanisms by which cells and organisms respond to genetic change
  • New frontiers in RNAi and its potential medical applications
  • Potential future implications for RNA interference
  • What advances from the field as a whole in the last couple of years are likely to revolutionize biology and medicine

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